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It generally improves over time

Mutations in these genes not only cause severe obesity but also frequently lead to a broad spectrum of neurological phenotypes, including intellectual disability, developmental delay, and behavioral abnormalities (e.g., autism-like features), highlighting the foundational role of hypothalamic development in energy homeostasis [12,14]

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By activating GLP-1 receptors in the brain, pancreas, and digestive tract, semaglutide reduces appetite, slows gastric emptying, and improves insulin sensitivity